Journal of Pediatrics and Advanced Neonatal Care

The Effects of Hydroalcholic Extract Polyherbal Formulation On Improving The Symptoms of Patients With COVID-19 In Hospital

2024-04-04T06:19:48+00:00

Objectives:

The pandemic of Coronavirus disease and severity of the infection and high mortality have almost unprecedented challenges in the health systems of most countries around the world. The present study aimed to evaluate the effect of hydroalcholic extract polyherbal formulation as entitled Imfluna on symptoms of COVID-19 infected patients. The polyherbal remedy for Imfluna had a significant effect on pulmonary involvement and reduced pulmonary involvement, the severity of shortness of breath, alanine aminotransferase (ALT), sodium (Na) in the post-test phase. Also, the average CBC count and percentage of blood oxygen saturation increased in both experimental and control groups. In addition to, the mean CBC count and percentage of blood oxygen saturation of the control group increased significantly.

Methods:

In this randomized double-blind placebo-controlled clinical trial a total of 60 voluntary confirmed COVID-19 patients were randomly assigned to placebo and Imfluna groups. Patients in each groups, in addition to receiving standard medications, took two 500 mg Imfluna capsules or placebo every 8 hours for 2 weeks. The patient's vital signs, pulmonary involvement, severity of shortness of breath, average blood CBC count, Percentage of blood oxygen saturation, liver and kidney function tests and study Na were evaluated.

Results:

The results showed that patients in the Imfluna-treated group had significantly greater improvement in pulmonary involvement, severity of shortness of breath, average blood CBC count, Percentage of blood oxygen saturation compared with the placebo group.

Conclusion:

Patients with COVID-19 who were treated with a Imfluna for 2 weeks had better comfort and fewer symptoms associated with the disease with no drug side effects.

Health effects and metabolic pathway of arsenic in children

2022-04-23T19:44:42+00:00

Our six years of field experience in Bangladesh showed that normally children under 11 years of age do not show arsenical skin manifestations. However, we have observed a few exceptions when (1) the arsenic content in water consumed by children is very high (≥1,000 µg/L) and (2) the arsenic content is not very high, but the children get poor nutrition. It appears that although 6.12% of 4,864 children showed arsenic skin lesions but hair and nail analysis of children (below 11 years) with or without arsenical skin lesions from affected villages of Bangladesh showed that 84% of the children had arsenic in hair more than the toxic level and 89% in nail above normal level. It appears that children living in arsenic affected villages have higher arsenic body burden but less dermatological symptoms. The value of arsenic excretion and arsenic intake per kg of body weight ratio for adults is 0.53 while that of the children is 0.69. This indicates total arsenic excretion is higher for children per kg of body weight than adults. The average values (n = 18) for speciation of arsenic in children urine are 15.60% In-As, 10.64% MMA, and 73.76% DMA. Overall percentage of MMA is higher, and DMA is lower in adults than children (average % MMA is 17.20 vs. 10.64 and % DMA is 64.62 vs. 73.76%, respectively). Therefore, the 2nd methylation step (MMA to DMA) could be more active in children than adults. The results indicate that the first reaction of the metabolism pathway is more active in adults than children, basically in adult’s male. Also shows a significant (t-test positive) increase in the values of the DMA/MMA ratio in children compared to adults of the exposed group (8.15 vs. 4.11, respectively). Moreover, it is also observed that the second methylation step in the arsenic metabolic pathway is more active in children than adults. Because there is no significant difference of the values of MMA/iAs ratio, but the values of DMA/MMA ratio are significantly different between adults and children of the exposed group (0.92 vs. 0.73 for MMA/Asi and 4.11 vs 8.15 for DMA/MMA, respectively). Thus, from these results we may conclude that children retain arsenic shorter in their body comparing adults.

The distribution of the values of DMA/MMA ratios with different ages of exposed humans shows that the DMA/MMA ratio decreases with increasing age, i.e., the methylation process decreases with increasing age. This observation also supports that the 2nd methylation process of arsenic (MMA to DMA) in children is better than the adults.

In conclusions, i) it appears that children living in arsenic affected villages have higher arsenic body burden but less dermatological symptoms, ii) children require more water than adults in terms of ml, per kg body weight, iii) the average values for speciation of arsenic in children urine are 15.60% In-As; 10.64% MMA, and 73.76% DMA), iv) methylation capacity (2nd methylation step) in children is better than adults, v) methylation process of arsenic (MMA to DMA) decreases with increasing age, and vi) may be children excrete arsenic faster i.e., retain less arsenic in their cellular system than adults.

Health conditions and COVID-19 vaccination status among the people in a union of Gopalganj district, Bangladesh

2024-04-04T06:27:49+00:00

In May 2022, the “Upendra Nath Chowdhury Trust (UNCTrust)” organized a Health Camp at Upendrapalli in Khagbari village of Ramshil union parishad, Kotalipara, Gopalganj, Bangladesh.Two hundredfifty-three people (166 females and 87 males) got their treatment, from ages 2 to 90 years old, in the Ramshil union parishad Health Camp program. There were four groups based on their ages: I. Pediatric Group, PG (> 0 to 14 years); II. Young Group, YG (15 to 47 years); III. Middle Age Group, MAG (48 to 63 years); and IV. Elderly Group, EG (≥64 years) people (Table 1). It shows that no significant age differences between females and males among the groups.

The major health problems of the participants in this program are asthma, blood pressure, and heart problems. In each group, there are a lot of people suffering from asthma problems. Even though pediatric group (PG) kids are also suffering. The males are suffering more than females with this disease. In PG, 20% females but 64% males; YG, 57% females and 54% males; MAG, 50% females and 67% males; and EG, 14.81% females and 67% males are suffering due to asthma problems. The next major health problem of these people is blood pressure. There were 40% females & 27% males in YG, 43% females & 37% males in MAG, and 59% females & 47% males in EG are suffering with blood pressure in these study groups. The data shows that the females are suffering more than males with blood pressure. According to our survey from the health camp participants, females are reported more than males with diabetes. The elderly group (EG; specially females) has a significantly higher percentage (11%) of diabetic patients compared to the other age groups. The data shows that there is a positive correlation with age.

The females were reported to smoke less comparing to the males, and these are 3% vs. 31%, 3% vs. 52%, and 4% vs. 52% among the YG, MAG, and EG, respectively. They don’t drink any kind of alcohol.

The most common foods for these villagers are rice, fish, and vegetables. They eat rice 3 times a day for seven days a week. These people drink almost 1200 ml to 1800 ml of water per day and there are more than 80% of people taking raw salt during their meal every time.

Almost 100% participants were vaccinated except pediatric group. From the PG, around 27% and 8% of females and males were vaccinated, respectively. Most of the participants from YG, MAG, and EG received both doses 1 & 2. The females of young group (YG) participants received the first two doses more than males (87% vs. 64%, respectively), but males received more booster doses compared to the females of the same age group (24% vs 9%, respectively). On the other hand, it was reversed for MAG people. In MAG people, females’ participants received the first two doses less than males (64% vs. 80%, respectively), but females received more booster doses compared to males of this age group (36% vs. 20%, respectively). The 73% of females and 81% of males of elderly group (EG) participants received doses 1 & 2, but 27% of females and 19% of males received booster doses. That means, more percent of females received booster doses compared to males in both MAG and EG.

In PG participants, the percentage of females (33%) taking medicine is a lot more compared to males (15%). But the percentage is higher for males taking medicine compared to females in both YG and MAG people participated in this program (64% vs. 56% in YG and 48% vs. 37% in MAG for males vs females, respectively). The percentage of elderly group (EG) participants in both females (73%) and males (72%) taking medicine are the highest compared to other age groups.

In conclusion, ahealth camp is very useful when it comes to learningabout the health status of the people at the root level, and with this event, we could also improve their health awareness. The organizer from the “Upendra Nath Chowdhury Trust (UNCTrust)” will organize Health Camp/Eye Camp and Workshop/Seminar once a year now which will help with the improving of health and education of the villagers in future.

Tailoring Tomorrow's Healthcare for Young Lives: Precision Medicine in Pediatrics and Advanced Neonatal Care

2023-10-18T10:46:35+00:00

Precision medicine has emerged as a groundbreaking approach to healthcare, tailoring medical treatment to the individual characteristics of each patient. While its applications have been widely discussed in the context of adult medicine, its role in pediatrics and advanced neonatal care is equally promising.

It is ushering in a new era in healthcare, with particular promise in the fields of pediatrics and advanced neonatal care. This article explores the transformative potential of precision medicine in optimizing treatment strategies for pediatric patients and infants in neonatal intensive care units (NICUs). By focusing on genetic, environmental, and lifestyle factors, precision medicine offers targeted therapies, early interventions, and improved outcomes. This paper reviews recent advancements, ethical considerations, and challenges associated with implementing precision medicine in pediatric and neonatal healthcare. The integration of genomic data, advanced diagnostic tools, and personalized treatment plans exemplifies the future of healthcare, promising enhanced quality of life for young patients. This article explores the current landscape of precision medicine in pediatrics, with a specific focus on neonatal care, highlighting its potential benefits, challenges, and prospects.

A Comprehensive Review of Intestinal Atresias

2021-08-05T17:41:13+00:00

Introduction: Intestinal atresia is an uncommon but challenging disease that requires a high level of suspicion for timely diagnosis and expeditious treatment. Its incidence ranges anywhere from 3.4 per 10,000 to 1 per 66,000 live births. Herein we present a comprehensive review of the various presentations of Intestinal Atresia and provide an algorithm for its evaluation.

Methods: A review of modern English Language in Index databases (PubMed, SCOPUS, EMBASE, MEDLINE, etc) in the English language was preformed. The etiology, pathophysiology, and management of the intestinal atresia at different levels of the intestinal tract were studied.

Results: Atresia is often diagnosed soon after birth and requires a multidisciplinary approach for optimal outcomes. Duodenal atresia is associated with many congenital anomalies and requires a multisystem workup once diagnosed. Jejuno-ilealatresia is the most common intestinal atresia and has fewer associated congenital defects than duodenal atresia. Colonic atresia is the rarest of the intestinal atresias but often has the best outcome as long as it is promptly diagnosed and treatment is not delayed.